KCNA6

Across TCGA cell cohorts, KCNA6 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNA6-associated genes across cancer lineages are C20orf85, PRAMEF9, and SCYGR10. Each is linked with KCNA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNA6-to-partner and partner-to-KCNA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf85 grouped by KCNA6-low versus KCNA6-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNA6→partner) and Y-score (partner→KCNA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C20orf85 →	+0.040	+3.930	<.001	.003	3	1
SKIN	PRAMEF9 →	+0.055	+4.196	<.001	.002	3	1
SKIN	SCYGR10 →	+0.146	+3.684	.002	.006	3	1
LARGE_INTESTINE	ASCL3 →	+0.144	+2.839	<.001	.004	3	1
LARGE_INTESTINE	HNRNPCL4 →	+0.036	+2.793	.006	.002	3	1
BLOOD_Leukemia	GNGT1 →	+0.053	+4.966	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

C20orf85 by KCNA6 expression — SKIN

Explore this box plot interactively →