KBTBD4

Across TCGA pan-cancer cohorts, KBTBD4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KBTBD4 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher KBTBD4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KBTBD4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

PDAC, UCEC, and LSCC are the cancer types where KBTBD4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	III,IV	0.308	0.891	.002	17	view →
UCEC	DFS	Tertile	II,III,IV	0.823	0.410	.049	4	view →
LSCC	DFS	Quartile	All	0.857	0.592	.023	2	view →
CCRCC	DFS	Quartile	All	0.955	0.355	.011	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KBTBD4–PDAC (DFS)

Open the PDAC breakdown →