KBTBD4

Across TCGA pan-cancer cohorts, KBTBD4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KBTBD4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where KBTBD4 RNA is repressed in tumor relative to normal tissue. In most cancer types KBTBD4 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and LIHC are the cancer types where KBTBD4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KBTBD4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.567	.002	8	view →
LUAD	All	All	−0.235	<.001	8	view →
LIHC	All	All	+0.567	<.001	7	view →
KIRC	Male	II,III,IV	−0.517	<.001	6	view →
BRCA	All	III,IV	+0.334	.009	6	view →
KIRP	Male	All	−0.727	<.001	4	view →
KICH	All	All	−0.558	.001	4	view →
CHOL	All	All	+1.191	<.001	3	view →
COAD	Female	All	+0.294	.017	3	view →
UCEC	All	All	−0.742	.001	2	view →
READ	All	All	−0.453	.002	2	view →
STAD	Male	II,III,IV	+0.438	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

KBTBD4–THCA

Open the THCA breakdown →