KBTBD4

Across TCGA patient cohorts, KBTBD4 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KBTBD4-associated genes across cancer lineages are Akt_pT308, 14-3-3_beta, and ERK2. Each is linked with KBTBD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KBTBD4-to-partner and partner-to-KBTBD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by KBTBD4-low versus KBTBD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KBTBD4→partner) and Y-score (partner→KBTBD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.529	+2.999	.037	.035	3	2
UCEC	14-3-3_beta →	-0.096	-2.295	.017	.033	3	1
UCEC	ERK2 →	+0.163	+2.115	.035	.017	3	1
UCEC	ACC_pS79 →	+0.378	+2.594	.006	.006	3	1
UCEC	Heregulin →	-0.127	-3.156	.010	.018	3	1
UCEC	HSP70 →	-0.411	-2.575	.011	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Akt_pT308 by KBTBD4 expression — UCEC

Explore this box plot interactively →