KBTBD4

Across TCGA cell cohorts, KBTBD4 mutation is significantly associated with the RNA expression of many other genes, with 81 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KBTBD4-associated genes across cancer lineages are METTL25, RPL36, and TRMT10A. Each is linked with KBTBD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KBTBD4-to-partner and partner-to-KBTBD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, METTL25 grouped by KBTBD4-low versus KBTBD4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KBTBD4→partner) and Y-score (partner→KBTBD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	METTL25 →	+0.551	+3.212	<.001	.006	3	1
LARGE_INTESTINE	RPL36 →	+0.688	+3.212	<.001	.006	3	1
LARGE_INTESTINE	TRMT10A →	+0.667	+3.212	.002	.006	3	1
LARGE_INTESTINE	SLC35A1 →	+0.653	+3.212	.007	.006	3	1
LARGE_INTESTINE	CEACAM3 →	+0.599	+2.754	<.001	.007	3	1
LARGE_INTESTINE	ZNF524 →	+0.597	+3.212	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

METTL25 by KBTBD4 expression — LARGE_INTESTINE

Explore this box plot interactively →