KBTBD2

Across TCGA pan-cancer cohorts, KBTBD2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated KBTBD2 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher KBTBD2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated KBTBD2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where KBTBD2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	0.503	0.892	<.001	51	view →
PDAC	OS	Quartile	All	0.587	0.969	<.001	29	view →
HNSC	DFS	Tertile	III,IV	0.673	0.932	.023	11	view →
UCEC	OS	Median	All	1.000	0.901	.005	10	view →
LSCC	DFS	Quartile	II,III,IV	0.568	0.856	.035	8	view →
CCRCC	OS	Quartile	II,III,IV	0.676	0.953	.032	7	view →
COAD	DFS	Quartile	III,IV	0.614	1.000	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

KBTBD2–LUAD (OS)

Open the LUAD breakdown →