KBTBD2

Across TCGA pan-cancer cohorts, KBTBD2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of KBTBD2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KBTBD2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KBTBD2 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

HNSC, LIHC, and COAD are the cancer types where KBTBD2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KBTBD2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.061	<.001	12	view →
LIHC	Female	II,III,IV	+0.865	<.001	9	view →
COAD	Male	All	+0.688	<.001	9	view →
KIRC	All	All	+0.454	<.001	9	view →
STAD	Male	II,III,IV	+0.944	<.001	8	view →
CHOL	Male	All	+1.666	<.001	5	view →
ESCA	All	All	+0.912	<.001	5	view →
KICH	Female	All	−0.762	<.001	4	view →
READ	All	All	+0.491	.005	4	view →
KIRP	All	IV	+0.740	.036	2	view →
LUAD	All	IV	+0.725	.018	2	view →
UCEC	All	All	−0.421	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

KBTBD2–HNSC

Open the HNSC breakdown →