KBTBD2

Across TCGA patient cohorts, KBTBD2 mutation is significantly associated with the RNA expression of many other genes, with 4,610 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KBTBD2-associated genes across cancer lineages are HMX2, MIR6071, and IGLJ1. Each is linked with KBTBD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KBTBD2-to-partner and partner-to-KBTBD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMX2 grouped by KBTBD2-low versus KBTBD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KBTBD2→partner) and Y-score (partner→KBTBD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMX2 →	+1.115	+2.389	<.001	<.001	3	2
CESC	MIR6071 →	+0.585	+4.320	<.001	.007	3	2
UCEC	IGLJ1 →	+0.399	+1.456	.001	.004	3	2
UCEC	IGHD3-16 →	+0.845	+1.626	<.001	.003	3	2
UCEC	IGHD3-9 →	+1.617	+2.397	<.001	<.001	3	2
UCEC	KLRK1 →	+0.172	+2.296	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,610 associations by consensus.

HMX2 by KBTBD2 expression — UCEC

Explore this box plot interactively →