KBTBD2

Across TCGA patient cohorts, KBTBD2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KBTBD2-associated genes across cancer lineages are p70-S6K_pT389, Caspase-7-cleavedD198, and C-Raf. Each is linked with KBTBD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KBTBD2-to-partner and partner-to-KBTBD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K_pT389 grouped by KBTBD2-low versus KBTBD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KBTBD2→partner) and Y-score (partner→KBTBD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K_pT389 →	-0.183	-2.000	.004	.029	3	2
UCEC	Caspase-7-cleavedD198 →	+0.577	+2.341	.003	.003	3	2
UCEC	C-Raf →	+0.148	+1.874	.001	.002	3	2
UCEC	eEF2 →	+0.313	+1.584	.008	.034	3	1
UCEC	EGFR_pY1068 →	-0.211	-1.874	.011	.002	3	1
UCEC	eIF4E →	+0.157	+1.584	.026	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

p70-S6K_pT389 by KBTBD2 expression — UCEC

Explore this box plot interactively →