Across TCGA patient cohorts, KAZN mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KAZN-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and PCNA. Each is linked with KAZN in more than 2 cancer types. Because this analysis shows association rather than direction, both KAZN-to-partner and partner-to-KAZN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KAZN→partner) and Y-score (partner→KAZN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.491	-2.321	<.001	.032	3	3
COAD	Caspase-7-cleavedD198 →	+1.092	+2.476	<.001	.009	3	3
UCEC	PCNA →	+0.179	+2.459	.013	.018	3	3
UCEC	PDCD4 →	-0.521	-2.201	<.001	<.001	3	3
SKCM	Smad4 →	+0.169	+3.169	.005	.019	3	2
COAD	eIF4E →	+0.204	+2.713	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Exploration

KAZN survival (RNA) · tumor vs normal (RNA) · all KAZN data types