KAT8

Across TCGA patient cohorts, KAT8 mutation is significantly associated with the RNA expression of many other genes, with 854 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KAT8-associated genes across cancer lineages are RNA5SP411, NARS1, and DNAJC19P8. Each is linked with KAT8 in more than 1 cancer types. Because this analysis shows association rather than direction, both KAT8-to-partner and partner-to-KAT8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP411 grouped by KAT8-low versus KAT8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KAT8→partner) and Y-score (partner→KAT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+1.194	+2.223	<.001	.002	3	2
UCEC	NARS1 →	+0.479	+2.906	.006	.002	3	2
SKCM	DNAJC19P8 →	+0.209	+3.923	<.001	.003	3	2
SKCM	MIR5094 →	+0.437	+4.178	.004	.002	3	2
UCEC	MTHFD2P3 →	+0.267	+3.015	<.001	<.001	3	2
UCEC	LINC01053 →	+0.192	+2.049	.009	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 854 associations by consensus.

RNA5SP411 by KAT8 expression — UCEC

Explore this box plot interactively →