KAT7

Across TCGA patient cohorts, KAT7 mutation is significantly associated with the RNA expression of many other genes, with 3,123 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KAT7-associated genes across cancer lineages are IGHD3-16, RNA5SP188, and IGHD6-13. Each is linked with KAT7 in more than 1 cancer types. Because this analysis shows association rather than direction, both KAT7-to-partner and partner-to-KAT7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD3-16 grouped by KAT7-low versus KAT7-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KAT7→partner) and Y-score (partner→KAT7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IGHD3-16 →	+1.077	+3.818	.007	.009	3	2
HNSC	RNA5SP188 →	+0.182	+5.023	<.001	.003	3	2
HNSC	IGHD6-13 →	+0.941	+3.685	.008	.009	3	2
HNSC	MAGEA7P →	+0.034	+3.952	.007	.005	3	2
CESC	NF1P10 →	+0.484	+6.569	<.001	.001	3	2
CESC	MTND4LP20 →	+0.168	+7.164	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,123 associations by consensus.

IGHD3-16 by KAT7 expression — HNSC

Explore this box plot interactively →