KAT6B

Across TCGA patient cohorts, KAT6B mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KAT6B-associated genes across cancer lineages are Claudin-7, FoxM1, and INPP4B. Each is linked with KAT6B in more than 2 cancer types. Because this analysis shows association rather than direction, both KAT6B-to-partner and partner-to-KAT6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Claudin-7 grouped by KAT6B-low versus KAT6B-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KAT6B→partner) and Y-score (partner→KAT6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Claudin-7 →	+0.991	+3.321	.001	.010	3	3
UCEC	FoxM1 →	+0.158	+1.125	.044	.033	3	2
UCEC	INPP4B →	-0.245	-2.000	.012	.002	3	2
UCEC	Ku80 →	+0.218	+1.543	.002	.002	3	2
UCEC	ATM →	-0.545	-2.649	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.403	+1.604	.024	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Claudin-7 by KAT6B expression — STAD

Explore this box plot interactively →