KAT6B

Across TCGA cell cohorts, KAT6B RNA expression is significantly associated with the go_rna of many other GO terms, with 5,157 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KAT6B-associated GO terms across cancer lineages are Subtelomeric heterochromatin formation, Regulation of sister chromatid cohesion, and Epigenetic regulation of gene expression. Each is linked with KAT6B in more than 15 cancer types. Because this analysis shows association rather than direction, both KAT6B-to-partner and partner-to-KAT6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Subtelomeric heterochromatin formation grouped by KAT6B-low versus KAT6B-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KAT6B→partner) and Y-score (partner→KAT6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Subtelomeric heterochromatin formation →	+0.114	+1.001	<.001	.002	3	16
SOFT_TISSUE	Regulation of sister chromatid cohesion →	+0.146	+0.792	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Epigenetic regulation of gene expression →	+0.056	+0.868	<.001	<.001	3	15
BLOOD_Lymphoma	mRNA destabilization →	+0.077	+1.163	<.001	<.001	3	14
SKIN	Viral translational termination-reinitiation →	+0.096	+0.760	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Positive regulation of organelle assembly →	+0.056	+0.675	.001	.006	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,157 associations by consensus.

Subtelomeric heterochromatin formation by KAT6B expression — LIVER

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