KAT5

Across TCGA pan-cancer cohorts, KAT5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KAT5 data layer compared with 23 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher KAT5 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KAT5 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

GBM, LSCC, and HNSC are the cancer types where KAT5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.650	0.403	<.001	23	view →
LSCC	OS	Median	II,III,IV	0.892	0.560	.002	20	view →
HNSC	OS	Median	III,IV	0.296	1.000	.005	20	view →
PDAC	OS	Median	All	1.000	0.720	.002	19	view →
CCRCC	OS	Quartile	All	1.000	0.798	.026	13	view →
LUAD	DFS	Tertile	II,III,IV	0.267	0.685	.012	5	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KAT5–GBM (OS)

Open the GBM breakdown →