KAT5

Across TCGA patient cohorts, KAT5 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KAT5-associated genes across cancer lineages are Ku80, MEK1, and MSH2. Each is linked with KAT5 in more than 1 cancer types. Because this analysis shows association rather than direction, both KAT5-to-partner and partner-to-KAT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by KAT5-low versus KAT5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KAT5→partner) and Y-score (partner→KAT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.234	+1.920	.013	.009	3	1
UCEC	MEK1 →	+0.503	+3.087	<.001	<.001	3	1
UCEC	MSH2 →	-0.301	-3.143	.001	.018	3	1
UCEC	Notch1 →	+0.204	+2.598	<.001	.005	3	1
UCEC	p62 Lck ligand →	+0.481	+4.169	<.001	<.001	3	1
UCEC	Annexin-1 →	+0.630	+3.604	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Ku80 by KAT5 expression — UCEC

Explore this box plot interactively →