KAT2A

Across TCGA patient cohorts, KAT2A mutation is significantly associated with the RNA expression of many other genes, with 2,175 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KAT2A-associated genes across cancer lineages are RNU6-604P, RNA5SP416, and DSN1. Each is linked with KAT2A in more than 1 cancer types. Because this analysis shows association rather than direction, both KAT2A-to-partner and partner-to-KAT2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-604P grouped by KAT2A-low versus KAT2A-high in THCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KAT2A→partner) and Y-score (partner→KAT2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	RNU6-604P →	+0.377	+7.962	<.001	.007	3	2
BRCA	RNA5SP416 →	+0.669	+7.471	<.001	.008	3	2
SKCM	DSN1 →	+0.740	+3.328	.001	.005	3	2
UCEC	TEX30 →	+0.612	+2.400	<.001	<.001	3	2
UCEC	FAM177A1 →	+0.293	+3.839	.003	<.001	3	2
UCEC	CENPU →	+0.744	+3.043	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,175 associations by consensus.

RNU6-604P by KAT2A expression — THCA

Explore this box plot interactively →