KAT14

Across TCGA cell cohorts, KAT14 mutation is significantly associated with the mutation status of many other genes, with 3,491 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KAT14-associated genes across cancer lineages are PYGB, RASAL3, and DSE. Each is linked with KAT14 in more than 4 cancer types. Because this analysis shows association rather than direction, both KAT14-to-partner and partner-to-KAT14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PYGB grouped by KAT14-low versus KAT14-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KAT14→partner) and Y-score (partner→KAT14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PYGB →	+2.662	+3.169	.001	.001	1	5
OVARY	RASAL3 →	+4.415	+4.977	.007	.007	1	4
UPPER_AERODIGESTIVE_TRACT	DSE →	+5.392	+5.392	.004	.004	1	4
OVARY	ZNF541 →	+4.415	+4.977	.007	.007	1	4
UPPER_AERODIGESTIVE_TRACT	SCUBE1 →	+5.392	+5.392	.004	.004	1	4
UPPER_AERODIGESTIVE_TRACT	CAMTA1 →	+4.392	+4.954	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,491 associations by consensus.

PYGB by KAT14 expression — BLOOD_Leukemia

Explore this box plot interactively →