KANSL3

Across TCGA patient cohorts, KANSL3 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KANSL3-associated genes across cancer lineages are Cyclin-E2, eEF2, and EGFR_pY1068. Each is linked with KANSL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both KANSL3-to-partner and partner-to-KANSL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by KANSL3-low versus KANSL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KANSL3→partner) and Y-score (partner→KANSL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.153	+1.700	.013	.040	3	3
UCEC	eEF2 →	+0.302	+3.321	.021	.009	3	2
UCEC	EGFR_pY1068 →	-0.288	-1.847	.001	.008	3	2
UCEC	PKC-delta_pS664 →	-0.134	-2.807	.002	.002	3	2
UCEC	ASNS →	+0.380	+2.321	.004	.005	3	2
UCEC	ATM →	-0.521	-2.700	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Cyclin-E2 by KANSL3 expression — UCEC

Explore this box plot interactively →