KANSL3

Across TCGA pan-cancer cohorts, KANSL3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of KANSL3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KANSL3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KANSL3 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

HNSC, LIHC, and KIRP are the cancer types where KANSL3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KANSL3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.692	<.001	11	view →
LIHC	Female	II,III,IV	+1.375	<.001	8	view →
KIRP	All	IV	+1.012	.005	8	view →
THCA	Male	All	−0.632	<.001	8	view →
LUAD	Female	II,III,IV	−0.580	<.001	7	view →
KICH	All	All	−0.716	<.001	6	view →
CHOL	All	All	+1.935	<.001	5	view →
STAD	All	II,III,IV	+0.695	.003	4	view →
COAD	All	All	+0.224	.008	3	view →
BLCA	Male	IV	−0.662	.016	2	view →
UCEC	All	All	−0.426	.002	2	view →
PRAD	All	All	−0.333	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

KANSL3–HNSC

Open the HNSC breakdown →