KANSL2

Across TCGA patient cohorts, KANSL2 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KANSL2-associated genes across cancer lineages are GAPDH, STAT3_pY705, and VHL. Each is linked with KANSL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KANSL2-to-partner and partner-to-KANSL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by KANSL2-low versus KANSL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KANSL2→partner) and Y-score (partner→KANSL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.408	+3.321	.038	.009	3	2
UCEC	STAT3_pY705 →	-0.472	-2.736	<.001	<.001	3	2
UCEC	VHL →	-0.891	-2.321	<.001	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.859	+2.434	<.001	.001	3	2
UCEC	C-Raf →	+0.208	+3.459	<.001	.005	3	2
UCEC	eEF2 →	+0.389	+3.459	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

GAPDH by KANSL2 expression — UCEC

Explore this box plot interactively →