KANSL2

Across TCGA pan-cancer cohorts, KANSL2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of KANSL2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KANSL2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KANSL2 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, COAD, and LIHC are the cancer types where KANSL2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KANSL2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.830	<.001	12	view →
COAD	Female	II,III,IV	+0.822	<.001	10	view →
LIHC	Female	II,III,IV	+1.034	<.001	9	view →
BLCA	All	All	+0.476	.001	8	view →
KIRC	All	All	+0.182	.002	7	view →
STAD	All	II,III,IV	+0.544	.003	6	view →
BRCA	All	II,III,IV	+0.275	<.001	6	view →
CHOL	All	All	+2.126	<.001	5	view →
LUSC	Male	All	+0.535	<.001	5	view →
READ	All	II,III,IV	+0.604	.006	4	view →
KIRP	Female	All	+0.567	.008	4	view →
LUAD	Male	All	+0.356	.003	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

KANSL2–HNSC

Open the HNSC breakdown →