KANSL2

Across TCGA cell cohorts, KANSL2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible KANSL2-associated genes across cancer lineages are CD300H, KRTAP4-4, and FAM110D. Each is linked with KANSL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KANSL2-to-partner and partner-to-KANSL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD300H grouped by KANSL2-low versus KANSL2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KANSL2→partner) and Y-score (partner→KANSL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CD300H →	+0.033	+4.415	<.001	.007	3	2
BLOOD_Lymphoma	KRTAP4-4 →	+0.024	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	FAM110D →	+0.107	+4.350	<.001	.005	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.017	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	PRAMEF9 →	+0.017	+5.813	<.001	<.001	3	1
SKIN	FCN2 →	+0.060	+6.022	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CD300H by KANSL2 expression — LARGE_INTESTINE

Explore this box plot interactively →