KANSL1L

Across TCGA pan-cancer cohorts, KANSL1L Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KANSL1L data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher KANSL1L Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated KANSL1L expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCS, UCEC, and LAML are the cancer types where KANSL1L Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	IV	0.132	0.718	.002	36	view →
UCEC	DFS	Median	II,III,IV	0.936	0.433	.011	20	view →
LAML	DFS	Median	All	0.165	0.581	.034	12	view →
LUAD	OS	Median	II,III,IV	0.163	0.750	.001	12	view →
PRAD	OS	Median	All	0.540	0.990	<.001	8	view →
SARC	DFS	Median	All	0.079	0.611	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KANSL1L–UCS (DFS)

Open the UCS breakdown →