KANSL1L

Across TCGA patient cohorts, KANSL1L mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KANSL1L-associated genes across cancer lineages are A-Raf_pS299, 4E-BP1, and C-Raf. Each is linked with KANSL1L in more than 2 cancer types. Because this analysis shows association rather than direction, both KANSL1L-to-partner and partner-to-KANSL1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by KANSL1L-low versus KANSL1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KANSL1L→partner) and Y-score (partner→KANSL1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.119	-1.906	.002	.015	3	2
UCEC	4E-BP1 →	+0.335	+3.807	<.001	<.001	3	2
UCEC	C-Raf →	+0.168	+1.459	<.001	.012	3	2
UCEC	Di-Ras3 →	-0.116	-2.571	.016	.010	3	2
COAD	PTEN →	+0.198	+2.815	.010	.036	3	1
COAD	Caspase-7-cleavedD198 →	+1.243	+2.815	.004	.036	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

A-Raf_pS299 by KANSL1L expression — UCEC

Explore this box plot interactively →