Across TCGA pan-cancer cohorts, KANK3 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated KANK3 data layer compared with 28 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher KANK3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KANK3 expression acts as an unfavorable survival marker.

LGG and ESCA are the cancer types where KANK3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.306	0.811	.007	6	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: KANK3 tumor-vs-normal RNA expression · all KANK3 data types