Across TCGA pan-cancer cohorts, KANK3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of KANK3’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where KANK3 RNA is repressed in tumor relative to normal tissue. In most cancer types KANK3 is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.
LUAD, KICH, and BLCA are the cancer types where KANK3 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KANK3 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.