Across TCGA patient cohorts, KANK3 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KANK3-associated genes across cancer lineages are beta-Catenin, 4E-BP1, and PTEN. Each is linked with KANK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KANK3-to-partner and partner-to-KANK3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KANK3→partner) and Y-score (partner→KANK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	beta-Catenin →	+0.577	+3.000	.048	.037	3	1
UCEC	4E-BP1 →	+0.346	+3.000	.027	.037	3	1
COAD	PTEN →	+0.170	+2.815	.027	.036	3	1
UCEC	ERK2 →	+0.264	+3.000	.017	.037	1	2
UCEC	IRS1 →	+0.344	+3.000	.004	.037	1	2
UCEC	ATM →	-0.575	-3.000	.028	.037	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

KANK3 survival (RNA) · tumor vs normal (RNA) · all KANK3 data types