Across TCGA patient cohorts, KANK2 mutation is significantly associated with the RNA expression of many other genes, with 3,354 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KANK2-associated genes across cancer lineages are NUS1, LYSMD3, and TYMSOS. Each is linked with KANK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both KANK2-to-partner and partner-to-KANK2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KANK2→partner) and Y-score (partner→KANK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NUS1 →	+0.498	+3.732	.002	<.001	3	3
UCEC	LYSMD3 →	+0.675	+2.736	<.001	<.001	3	3
UCEC	TYMSOS →	+0.657	+2.233	<.001	.005	3	3
UCEC	C18orf32 →	+0.472	+3.040	<.001	<.001	3	3
COAD	HPF1 →	+0.615	+3.472	<.001	.002	3	3
UCEC	CTTNBP2 →	-0.777	-1.826	.005	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,354 associations by consensus.

Exploration

KANK2 survival (RNA) · tumor vs normal (RNA) · all KANK2 data types