KALRN

Across TCGA pan-cancer cohorts, KALRN Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated KALRN data layer compared with 20 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher KALRN Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated KALRN expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.

KIRP, DLBC, and SCLC are the cancer types where KALRN Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.037	0.920	<.001	24	view →
DLBC	OS	Median	II,III,IV	0.172	0.949	<.001	18	view →
SCLC	DFS	Median	All	0.168	0.638	<.001	15	view →
UCEC	DFS	Median	All	0.778	0.625	.019	14	view →
BLCA	OS	Median	IV	0.289	0.599	.008	12	view →
STAD	OS	Median	II,III,IV	0.228	0.710	.014	9	view →
SKCM	DFS	Median	III,IV	0.184	0.553	.028	6	view →
LUAD	OS	Median	II,III,IV	0.297	0.754	.005	6	view →
KICH	DFS	Median	All	0.121	0.867	.023	5	view →
SARC	OS	Median	All	0.515	0.827	<.001	4	view →
COAD	DFS	Median	All	0.882	0.673	.029	3	view →
CESC	DFS	Median	All	0.862	0.516	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

KALRN–KIRP (DFS)

Open the KIRP breakdown →