KALRN

Across TCGA pan-cancer cohorts, KALRN RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of KALRN’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KALRN RNA is repressed in tumor relative to normal tissue. In most cancer types KALRN is over-expressed in tumor, although a few such as HNSC and KICH show the opposite, repressed pattern.

HNSC, KICH, and KIRC are the cancer types where KALRN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KALRN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−1.093	<.001	10	view →
KICH	Male	II,III,IV	−0.949	<.001	8	view →
KIRC	Female	All	+0.689	<.001	8	view →
READ	Male	All	−1.183	.007	6	view →
BRCA	All	All	−0.793	<.001	6	view →
COAD	Female	II,III,IV	−0.793	<.001	5	view →
LUSC	Female	II,III,IV	−0.917	.001	2	view →
UCEC	All	All	−0.817	<.001	2	view →
LUAD	Female	All	−0.243	.034	2	view →
STAD	Female	III,IV	−1.000	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

KALRN–HNSC

Open the HNSC breakdown →