KALRN

Across TCGA patient cohorts, KALRN mutation is significantly associated with the RNA expression of many other genes, with 10,056 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KALRN-associated genes across cancer lineages are SKA2, CDCA2, and CENPA. Each is linked with KALRN in more than 5 cancer types. Because this analysis shows association rather than direction, both KALRN-to-partner and partner-to-KALRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA2 grouped by KALRN-low versus KALRN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KALRN→partner) and Y-score (partner→KALRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA2 →	+0.512	+1.406	<.001	<.001	3	6
HNSC	CDCA2 →	+0.801	+3.011	<.001	<.001	3	6
LUAD	CENPA →	+0.961	+2.535	<.001	<.001	3	6
LUAD	KIF11 →	+0.699	+1.819	.001	.002	3	6
UCEC	CHAF1A →	+0.758	+2.758	<.001	<.001	3	6
UCEC	BUB3 →	+0.465	+1.292	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,056 associations by consensus.

SKA2 by KALRN expression — UCEC

Explore this box plot interactively →