KALRN

Across TCGA cell cohorts, KALRN mutation is significantly associated with the RNA expression of many other genes, with 2,226 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KALRN-associated genes across cancer lineages are TSPAN16, METTL4, and ACBD5. Each is linked with KALRN in more than 2 cancer types. Because this analysis shows association rather than direction, both KALRN-to-partner and partner-to-KALRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSPAN16 grouped by KALRN-low versus KALRN-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KALRN→partner) and Y-score (partner→KALRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TSPAN16 →	+0.121	+3.369	<.001	.003	3	3
LARGE_INTESTINE	METTL4 →	+0.650	+2.043	<.001	.001	3	3
LARGE_INTESTINE	ACBD5 →	+0.886	+3.584	<.001	<.001	3	3
LARGE_INTESTINE	KDSR →	+0.835	+2.545	<.001	<.001	3	3
LARGE_INTESTINE	PBK →	+0.878	+2.043	<.001	.001	3	3
LARGE_INTESTINE	ELP5 →	+0.789	+3.212	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,226 associations by consensus.

TSPAN16 by KALRN expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →