JUN

Across TCGA patient cohorts, JUN mutation is significantly associated with the RNA expression of many other genes, with 3,508 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JUN-associated genes across cancer lineages are RNU6-43P, LINC02665, and RPL30P10. Each is linked with JUN in more than 1 cancer types. Because this analysis shows association rather than direction, both JUN-to-partner and partner-to-JUN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-43P grouped by JUN-low versus JUN-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JUN→partner) and Y-score (partner→JUN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-43P →	+0.358	+4.068	<.001	.001	3	2
LUSC	LINC02665 →	+0.093	+4.438	.003	.006	3	2
LUSC	RPL30P10 →	+0.186	+4.036	<.001	.001	3	2
UCEC	RNA5SP391 →	+0.162	+4.156	<.001	.004	3	2
UCEC	MIR548A1 →	+0.132	+3.386	<.001	.002	3	2
UCEC	NPM1P3 →	+0.245	+2.321	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,508 associations by consensus.

RNU6-43P by JUN expression — CESC

Explore this box plot interactively →