JUN

Across TCGA pan-cancer cohorts, JUN RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of JUN’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where JUN RNA is repressed in tumor relative to normal tissue. In most cancer types JUN is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

THCA, BLCA, and KICH are the cancer types where JUN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in JUN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−2.298	<.001	11	view →
BLCA	All	IV	−1.528	<.001	10	view →
KICH	Female	III,IV	−3.143	<.001	9	view →
UCEC	All	II,III,IV	−2.239	<.001	6	view →
BRCA	All	III,IV	−1.673	<.001	6	view →
LUSC	All	II,III,IV	−1.149	<.001	6	view →
LUAD	All	All	−0.878	<.001	6	view →
STAD	Female	III,IV	−1.755	.005	3	view →
LIHC	All	All	−0.806	<.001	3	view →
KIRP	All	All	−0.679	.004	2	view →
COAD	Female	All	+0.357	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

JUN–THCA

Open the THCA breakdown →