JRK

Across TCGA patient cohorts, JRK mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JRK-associated genes across cancer lineages are JNK2, Annexin-1, and ERK2. Each is linked with JRK in more than 1 cancer types. Because this analysis shows association rather than direction, both JRK-to-partner and partner-to-JRK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by JRK-low versus JRK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JRK→partner) and Y-score (partner→JRK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.248	+2.348	.001	.018	3	2
UCEC	Annexin-1 →	+0.613	+3.459	.002	.005	3	2
UCEC	ERK2 →	+0.192	+2.584	.009	.010	3	1
UCEC	HER2 →	+0.428	+1.874	.014	.049	3	1
UCEC	Ku80 →	+0.202	+1.594	.025	.042	3	1
UCEC	MEK1 →	+0.332	+2.115	.018	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

JNK2 by JRK expression — UCEC

Explore this box plot interactively →