JRK

Across TCGA pan-cancer cohorts, JRK RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of JRK’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where JRK RNA is more highly expressed in tumor relative to normal tissue. In most cancer types JRK is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

COAD, THCA, and LIHC are the cancer types where JRK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in JRK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+1.148	<.001	11	view →
THCA	Male	II,III,IV	−1.093	<.001	11	view →
LIHC	Female	II,III,IV	+1.148	<.001	9	view →
STAD	Male	II,III,IV	+0.960	<.001	6	view →
BLCA	Female	III,IV	+0.902	.006	6	view →
KIRP	Male	All	−0.737	<.001	6	view →
BRCA	Female	All	−0.461	<.001	6	view →
CHOL	All	All	+2.448	<.001	5	view →
LUSC	Male	III,IV	+1.157	<.001	5	view →
READ	All	All	+0.741	.003	5	view →
HNSC	All	All	+0.264	.034	4	view →
KIRC	Male	II,III,IV	−0.294	.025	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

JRK–COAD

Open the COAD breakdown →