JPH4

Across TCGA patient cohorts, JPH4 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JPH4-associated genes across cancer lineages are JNK2, ASNS, and 4E-BP1. Each is linked with JPH4 in more than 1 cancer types. Because this analysis shows association rather than direction, both JPH4-to-partner and partner-to-JPH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by JPH4-low versus JPH4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JPH4→partner) and Y-score (partner→JPH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.285	+2.916	<.001	<.001	3	2
UCEC	ASNS →	+0.453	+2.584	<.001	.010	3	2
UCEC	4E-BP1 →	+0.348	+2.169	<.001	.003	3	2
UCEC	C-Raf →	+0.141	+1.415	.008	.046	3	2
UCEC	EGFR_pY1068 →	-0.253	-2.321	.007	.033	3	1
UCEC	A-Raf_pS299 →	-0.172	-2.906	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

JNK2 by JPH4 expression — UCEC

Explore this box plot interactively →