JPH4

Across TCGA pan-cancer cohorts, JPH4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of JPH4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where JPH4 RNA is repressed in tumor relative to normal tissue. In most cancer types JPH4 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and KIRP are the cancer types where JPH4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in JPH4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−1.528	<.001	12	view →
KICH	Male	II,III,IV	−2.106	<.001	11	view →
KIRP	Male	II,III,IV	−1.479	<.001	11	view →
COAD	Male	All	−0.740	<.001	11	view →
LUSC	Male	III,IV	−1.890	<.001	9	view →
LUAD	Female	III,IV	−1.812	<.001	9	view →
UCEC	All	III,IV	−4.303	<.001	6	view →
BRCA	Female	II,III,IV	−0.527	<.001	6	view →
STAD	All	All	−0.341	.007	6	view →
READ	All	All	−0.810	<.001	5	view →
PRAD	All	All	−1.526	<.001	2	view →
ESCA	Female	All	−0.730	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

JPH4–KIRC

Open the KIRC breakdown →