JOSD2

Across TCGA patient cohorts, JOSD2 protein abundance is significantly associated with the protein abundance of many other proteins, with 9,760 significant associations in total. GBM shows the largest number of these associations.

The most reproducible JOSD2-associated proteins across cancer lineages are NUDT18, SF3A3, and SNRPD3. Each is linked with JOSD2 in more than 3 cancer types. Because this analysis shows association rather than direction, both JOSD2-to-partner and partner-to-JOSD2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, JOSD2 versus NUDT18 in GBM, with a Pearson correlation of 0.40.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (JOSD2→partner) and Y-score (partner→JOSD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NUDT18 →	+0.327	+0.610	<.001	<.001	3	4
LSCC	SF3A3 →	-0.197	-0.305	<.001	<.001	3	4
GBM	SNRPD3 →	-0.282	-0.519	<.001	<.001	3	4
LSCC	RBM12B →	-0.291	-0.296	<.001	<.001	3	4
GBM	HNRNPK →	-0.245	-0.496	<.001	<.001	3	3
LSCC	IK →	-0.201	-0.337	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,760 associations by consensus.

JOSD2 vs NUDT18 — GBM

Explore this scatter interactively →