JMJD8

Across TCGA patient cohorts, JMJD8 mutation is significantly associated with the RNA expression of many other genes, with 97 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JMJD8-associated genes across cancer lineages are LONRF2P2, RNU6-293P, and DNAAF4-CCPG1. Each is linked with JMJD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both JMJD8-to-partner and partner-to-JMJD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LONRF2P2 grouped by JMJD8-low versus JMJD8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JMJD8→partner) and Y-score (partner→JMJD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LONRF2P2 →	+0.064	+4.513	.009	.009	3	2
BLCA	RNU6-293P →	+0.308	+5.038	<.001	.009	3	2
SKCM	DNAAF4-CCPG1 →	+0.012	+4.296	.007	.008	3	2
BLCA	RNU6-1318P →	+0.408	+5.588	<.001	.004	3	1
HNSC	RPSAP35 →	+0.054	+5.303	.002	.006	3	1
HNSC	QTRT1P1 →	+0.066	+5.736	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

LONRF2P2 by JMJD8 expression — SKCM

Explore this box plot interactively →