JMJD8

Across TCGA pan-cancer cohorts, JMJD8 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of JMJD8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where JMJD8 RNA is repressed in tumor relative to normal tissue. In most cancer types JMJD8 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and COAD are the cancer types where JMJD8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in JMJD8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.233	<.001	10	view →
THCA	Male	III,IV	−1.042	<.001	10	view →
COAD	Female	All	+0.765	<.001	10	view →
LIHC	Female	II,III,IV	+0.747	<.001	9	view →
KIRP	All	II,III,IV	+0.506	<.001	9	view →
BRCA	Female	All	+0.343	<.001	6	view →
BLCA	Male	All	−0.586	.023	5	view →
HNSC	All	All	+0.321	.003	5	view →
CHOL	All	All	+1.426	<.001	3	view →
UCEC	All	All	−0.317	.042	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

JMJD8–KICH

Open the KICH breakdown →