JMJD8

Across TCGA patient cohorts, JMJD8 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JMJD8-associated genes across cancer lineages are SCD, STAT5a, and 14-3-3_beta. Each is linked with JMJD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both JMJD8-to-partner and partner-to-JMJD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCD grouped by JMJD8-low versus JMJD8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JMJD8→partner) and Y-score (partner→JMJD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SCD →	-0.128	-2.986	.044	.037	3	1
UCEC	STAT5a →	+0.525	+3.000	.023	.037	3	1
UCEC	14-3-3_beta →	-0.134	-2.986	.021	.037	2	1
UCEC	PKC-a →	+0.572	+3.000	.014	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

SCD by JMJD8 expression — UCEC

Explore this box plot interactively →