JMJD8

Across TCGA cell cohorts, JMJD8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,055 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible JMJD8-associated GO terms across cancer lineages are Positive regulation of intracellular estrogen receptor signaling pathway, mRNA alternative polyadenylation, and Spliceosomal tri-snRNP complex assembly. Each is linked with JMJD8 in more than 9 cancer types. Because this analysis shows association rather than direction, both JMJD8-to-partner and partner-to-JMJD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular estrogen receptor signaling pathway grouped by JMJD8-low versus JMJD8-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (JMJD8→partner) and Y-score (partner→JMJD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.179	+1.035	<.001	<.001	3	10
BLOOD_Lymphoma	mRNA alternative polyadenylation →	+0.065	+0.954	<.001	<.001	3	9
SKIN	Spliceosomal tri-snRNP complex assembly →	+0.081	+0.704	.001	.006	3	9
LARGE_INTESTINE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.111	+1.134	<.001	<.001	3	9
BLOOD_Lymphoma	Positive regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.088	+0.871	.002	<.001	3	9
BLOOD_Myeloma	Negative regulation of mRNA processing →	+0.106	+1.337	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,055 associations by consensus.

Positive regulation of intracellular estrogen receptor signaling pathway by JMJD8 expression — LARGE_INTESTINE

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