JMJD8

Across TCGA cell cohorts, JMJD8 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible JMJD8-associated genes across cancer lineages are OR6V1, DEFB118, and CHIA. Each is linked with JMJD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both JMJD8-to-partner and partner-to-JMJD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6V1 grouped by JMJD8-low versus JMJD8-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JMJD8→partner) and Y-score (partner→JMJD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR6V1 →	+0.042	+4.467	<.001	.004	3	2
BREAST	DEFB118 →	+0.026	+4.196	<.001	.006	3	1
BREAST	CHIA →	+0.066	+4.415	<.001	.001	3	1
BREAST	IL9 →	+0.032	+4.196	<.001	.006	3	1
BREAST	C3orf22 →	+0.063	+4.064	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	C1orf146 →	+0.028	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

OR6V1 by JMJD8 expression — SKIN

Explore this box plot interactively →