JHY

Across TCGA cell cohorts, JHY mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible JHY-associated genes across cancer lineages are CCDC182, HMGB4, and FAM71C. Each is linked with JHY in more than 1 cancer types. Because this analysis shows association rather than direction, both JHY-to-partner and partner-to-JHY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC182 grouped by JHY-low versus JHY-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JHY→partner) and Y-score (partner→JHY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CCDC182 →	+0.026	+4.643	<.001	.008	3	1
OESOPHAGUS	HMGB4 →	+0.043	+4.906	<.001	.006	3	1
OESOPHAGUS	FAM71C →	+0.023	+4.906	<.001	.006	3	1
LARGE_INTESTINE	SKA1 →	+0.767	+3.212	.009	.006	3	1
LARGE_INTESTINE	OR2C1 →	+0.098	+2.725	<.001	.003	3	1
LARGE_INTESTINE	CNTLN →	+1.027	+3.212	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

CCDC182 by JHY expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →