JAML

Across TCGA patient cohorts, JAML mutation is significantly associated with the RNA expression of many other genes, with 1,867 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JAML-associated genes across cancer lineages are BPY2DP, LINC00326, and EEF1E1-BLOC1S5. Each is linked with JAML in more than 2 cancer types. Because this analysis shows association rather than direction, both JAML-to-partner and partner-to-JAML results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPY2DP grouped by JAML-low versus JAML-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAML→partner) and Y-score (partner→JAML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	BPY2DP →	+0.145	+4.824	<.001	.002	3	3
READ	LINC00326 →	+0.826	+5.421	<.001	.005	3	2
READ	EEF1E1-BLOC1S5 →	+0.204	+5.219	<.001	.006	3	2
UCEC	RNA5SP432 →	+0.493	+2.255	<.001	.004	3	2
CESC	RNU6-912P →	+0.347	+5.010	<.001	.009	3	2
UCEC	NCAPD3 →	+0.866	+3.815	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,867 associations by consensus.

BPY2DP by JAML expression — COAD

Explore this box plot interactively →