JAK1

Across TCGA patient cohorts, JAK1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JAK1-associated genes across cancer lineages are STAT3_pY705, ATM, and Cyclin-B1. Each is linked with JAK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both JAK1-to-partner and partner-to-JAK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by JAK1-low versus JAK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAK1→partner) and Y-score (partner→JAK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.415	-1.736	<.001	<.001	3	3
UCEC	ATM →	-0.423	-1.986	.001	.008	3	3
UCEC	Cyclin-B1 →	+0.500	+1.536	.001	.002	3	3
SKCM	PRAS40_pT246 →	+0.217	+2.820	.011	.035	3	2
UCEC	mTOR_pS2448 →	-0.108	-1.986	.011	.008	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.331	-1.334	.010	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

STAT3_pY705 by JAK1 expression — UCEC

Explore this box plot interactively →