JAK1

Across TCGA pan-cancer cohorts, JAK1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated JAK1 data layer compared with 10 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher JAK1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated JAK1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

KIRC, BRCA, and UCS are the cancer types where JAK1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.730	0.538	<.001	135	view →
BRCA	DFS	Tertile	All	0.971	0.917	<.001	74	view →
UCS	DFS	Tertile	IV	0.942	0.363	.024	24	view →
HNSC	DFS	Tertile	All	0.772	0.640	.007	21	view →
LUSC	OS	Median	III,IV	0.407	0.892	.003	20	view →
OV	OS	Median	III,IV	0.269	0.359	.007	18	view →
ACC	DFS	Quartile	All	0.123	0.768	.009	16	view →
KICH	DFS	Median	II,III,IV	0.571	0.920	.005	15	view →
COAD	DFS	Quartile	IV	0.715	0.355	.015	15	view →
SKCM	OS	Median	II,III,IV	0.892	0.776	.014	13	view →
READ	OS	Median	All	0.886	0.525	.025	12	view →
CESC	DFS	Tertile	III,IV	0.286	0.736	.041	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

JAK1–KIRC (OS)

Open the KIRC breakdown →