JAK1

Across TCGA cell cohorts, JAK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,784 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible JAK1-associated GO terms across cancer lineages are Interleukin-9-mediated signaling pathway, Cellular response to interleukin-9, and Interleukin-2-mediated signaling pathway. Each is linked with JAK1 in more than 17 cancer types. Because this analysis shows association rather than direction, both JAK1-to-partner and partner-to-JAK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Interleukin-9-mediated signaling pathway grouped by JAK1-low versus JAK1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (JAK1→partner) and Y-score (partner→JAK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Interleukin-9-mediated signaling pathway →	+0.271	+1.428	<.001	<.001	3	18
BREAST	Cellular response to interleukin-9 →	+0.271	+1.428	<.001	<.001	3	18
BREAST	Interleukin-2-mediated signaling pathway →	+0.306	+1.227	.007	<.001	3	17
LUNG_NSCLC_LUSC	Response to interleukin-9 →	+0.242	+1.330	<.001	<.001	3	17
BREAST	Cellular response to interleukin-2 →	+0.306	+1.227	.007	<.001	3	17
LUNG_SCLC	Interleukin-10-mediated signaling pathway →	+0.308	+1.602	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,784 associations by consensus.

Interleukin-9-mediated signaling pathway by JAK1 expression — BREAST

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